abstract：:Immune responses to minor histocompatibility antigens are poorly understood and present substantial barriers to successful solid tissue and bone marrow transplantation among MHC-matched individuals. We exploited a unique positional cloning approach relying on the potent negative selection capability of cytotoxic T cel...

journal_title：Immunity

authors： Zuberi AR,Christianson GJ,Mendoza LM,Shastri N,Roopenian DC

更新日期：1998-11-01 00:00:00

abstract：:mel-18 is a mammalian Polycomb group gene encoding a transcriptional repressor with tumor suppressive activity. Overexpression of mel-18 in mice results in cell cycle arrest of B cells upon B cell receptor stimulation with downregulation of c-myc. This phenotype is rescued in mel-18/c-myc double-transgenic mice, sugge...

journal_title：Immunity

authors： Tetsu O,Ishihara H,Kanno R,Kamiyasu M,Inoue H,Tokuhisa T,Taniguchi M,Kanno M

更新日期：1998-10-01 00:00:00

abstract：:Aiolos encodes a zinc finger DNA-binding protein that is highly expressed in mature B cells and is homologous to Ikaros. In the periphery of mice homozygous for an Aiolos-null mutation, B cells exhibit an activated cell surface phenotype and undergo augmented antigen receptor (BCR)-mediated in vitro proliferative resp...

journal_title：Immunity

authors： Wang JH,Avitahl N,Cariappa A,Friedrich C,Ikeda T,Renold A,Andrikopoulos K,Liang L,Pillai S,Morgan BA,Georgopoulos K

更新日期：1998-10-01 00:00:00

abstract：:Clonal selection theories postulate that lymphocyte fate is regulated by antigen receptor specificity. However, lymphocyte apoptosis is induced through nonantigen-specific receptors such as Fas (CD95/APO-1) or TNFR. We define a selective TCR that controls apoptosis by Fas or TNFR stimulation. Variant ligands can deliv...

journal_title：Immunity

authors： Combadière B,Reis e Sousa C,Trageser C,Zheng LX,Kim CR,Lenardo MJ

更新日期：1998-09-01 00:00:00

abstract：:Epstein-Barr virus (EBV) establishes a persistent latent infection in peripheral B lymphocytes in humans and is associated with a variety of malignancies and proliferative disorders. Latent membrane protein 2A (LMP2A) is one of only two viral proteins expressed in latently infected B lymphocytes in vivo. LMP2A blocks ...

journal_title：Immunity

authors： Caldwell RG,Wilson JB,Anderson SJ,Longnecker R

更新日期：1998-09-01 00:00:00

abstract：:The structure of H-2Dd complexed with the HIV-derived peptide P18-I10 (RGPGRAFVTI) has been determined by X-ray crystallography at 2.4 A resolution. This MHC class I molecule has an unusual binding motif with four anchor residues in the peptide (G2, P3, R/K/H5, and I/L/F9 or 10). The cleft architecture of H-2Dd includ...

journal_title：Immunity

authors： Achour A,Persson K,Harris RA,Sundbäck J,Sentman CL,Lindqvist Y,Schneider G,Kärre K

更新日期：1998-08-01 00:00:00

abstract：:Three mutant immunoglobulin heavy chain (IgH) insertion mice were generated in which a targeted nonfunctional IgH passenger transgene was either devoid of promoter (pdelta) or was placed under the transcriptional control of either its own RNA polymerase II-dependent IgH promoter (pII) or a RNA polymerase I-dependent p...

journal_title：Immunity

authors： Fukita Y,Jacobs H,Rajewsky K

更新日期：1998-07-01 00:00:00

abstract：:To understand how orally introduced antigen regulates peripheral immune responses, we fed cytochrome c protein to mice transgenic for the beta chain of a cytochrome c-specific TCR and followed the antigen-specific T cell responses with a cyt c/I-Ek tetramer staining reagent. We find that within 6 hr of cytochrome c ad...

journal_title：Immunity

authors： Gütgemann I,Fahrer AM,Altman JD,Davis MM,Chien YH

更新日期：1998-06-01 00:00:00

abstract：:We have investigated the lymphohematopoietic potentials of endothelial cells (EC) and hematopoietic cells (HPC) sorted from embryos. Expression of VE-cadherin, CD45, and Ter119 was used to distinguish EC (VE-cadherin+CD45-Ter119-) from HPC (VE-cadherin-CD45+). Thus defined, EC population takes up acetylated LDL and co...

journal_title：Immunity

authors： Nishikawa SI,Nishikawa S,Kawamoto H,Yoshida H,Kizumoto M,Kataoka H,Katsura Y

更新日期：1998-06-01 00:00:00

abstract：:Proliferation of memory-phenotype (CD44hi) CD8+ cells induced by infectious agents can be mimicked by injection of type I interferon (IFN I) and by IFN I-inducing agents such as lipopolysaccharide and Poly I:C; such proliferation does not affect naive T cells and appears to be TCR independent. Since IFN I inhibits pro...

journal_title：Immunity

authors： Zhang X,Sun S,Hwang I,Tough DF,Sprent J

更新日期：1998-05-01 00:00:00

abstract：:Membrane recruitment of SHIP is responsible for the inhibitory signal generated by FcgammaRIIB coligation to the BCR. By reducing the level of PIP3, SHIP regulates the association of the tyrosine kinase Btk with the membrane through PH domain-phosphoinositol lipid interactions. Inhibition of BCR signaling by either Fc...

journal_title：Immunity

authors： Bolland S,Pearse RN,Kurosaki T,Ravetch JV

更新日期：1998-04-01 00:00:00

abstract：:The ability of human CD1b molecules to present nonpeptide antigens is suggested by the T cell recognition of microbial lipids and lipoglycans in the presence of CD1b-expressing antigen-presenting cells. We demonstrate the high-affinity interaction of CD1b molecules with the acyl side chains of known T cell antigens, l...

journal_title：Immunity

authors： Ernst WA,Maher J,Cho S,Niazi KR,Chatterjee D,Moody DB,Besra GS,Watanabe Y,Jensen PE,Porcelli SA,Kronenberg M,Modlin RL

更新日期：1998-03-01 00:00:00

abstract：:We analyzed the participation of a predominant B cell clonotype in the anti-arsonate immune response of mice in which Bcl-2 expression was enforced in B cells. Many of the antibodies expressed by the arsonate-induced memory compartment of these mice were "dual-reactive," displaying increased affinity acquired via V re...

journal_title：Immunity

authors： Hande S,Notidis E,Manser T

更新日期：1998-02-01 00:00:00

abstract：:A cDNA clone encoding the human homolog of rat Jagged1 was isolated from normal human marrow. Analyses of human stromal cell lines indicate that this gene, designated hJagged1, is expressed by marrow stromal cells typified by the cell line HS-27a, which supports the long-term maintenance of hematopoietic progenitor ce...

journal_title：Immunity

authors： Li L,Milner LA,Deng Y,Iwata M,Banta A,Graf L,Marcovina S,Friedman C,Trask BJ,Hood L,Torok-Storb B

更新日期：1998-01-01 00:00:00

abstract：:The expression of KIR and CD94:NKG2 receptors was determined for more than 100 natural killer (NK) cell clones obtained from two blood donors who differ in their HLA class I and KIR genes. More than 98% of the clones were inhibited by individual autologous class I allotypes, and every clone was inhibited by the combin...

journal_title：Immunity

authors： Valiante NM,Uhrberg M,Shilling HG,Lienert-Weidenbach K,Arnett KL,D'Andrea A,Phillips JH,Lanier LL,Parham P

更新日期：1997-12-01 00:00:00

abstract：:Transcription factors of the NFAT family play a critical role in the immune response by activating the expression of cytokines and other inducible genes in antigen-stimulated cells. Here we show that a member of this family, NFAT1, is involved in down-regulating the late phase of IL-4 gene transcription, thus inhibiti...

journal_title：Immunity

authors： Kiani A,Viola JP,Lichtman AH,Rao A

更新日期：1997-12-01 00:00:00

abstract：:Cell death in B cell terminal differentiation rapidly follows cell cycle arrest in IL-6 differentiation of EBV-immortalized, IgG-bearing human lymphoblastoid cells in vitro. G1 arrest is now found to coincide with repression of EBNA2 and LMP1, two EBV genes essential for B cell transformation, without activation of th...

journal_title：Immunity

authors： Altmeyer A,Simmons RC,Krajewski S,Reed JC,Bornkamm GW,Chen-Kiang S

更新日期：1997-11-01 00:00:00

abstract：:For a brief period during fetal lymph node organogenesis in mice, lymph node postcapillary high endothelial venules surprisingly express the Peyer's patch addressin MAdCAM-1. This expression allows initial seeding of this incipient structure by two unusual lymphocyte populations selectively expressing the Peyer's patc...

journal_title：Immunity

authors： Mebius RE,Rennert P,Weissman IL

更新日期：1997-10-01 00:00:00

abstract：:Recent experiments have suggested that tumor necrosis factor alpha (TNFalpha) can down-regulate islet-specific T cells and prevent the development of autoimmune diabetes. Here we demonstrate that transgenic mice expressing both TNFalpha and the Leishmania major LACK antigen in the pancreas (RIP-TNFalpha/RIP-LACK) exhi...

journal_title：Immunity

authors： McSorley SJ,Soldera S,Malherbe L,Carnaud C,Locksley RM,Flavell RA,Glaichenhaus N

更新日期：1997-09-01 00:00:00

abstract：:T cell receptor (TCR) transgenic mice specific for hen egg lysozyme (HEL) were crossed with mice expressing HEL on the thyroid epithelium, on pancreatic islet beta cells, or systemically. Depending on the pattern of HEL expression, deletion of double-positive thymocytes ranged from minimal to complete, and peripheral ...

journal_title：Immunity

authors： Akkaraju S,Ho WY,Leong D,Canaan K,Davis MM,Goodnow CC

更新日期：1997-08-01 00:00:00

abstract：:The signaling pathways linked to membrane immunoglobulin (mIg) that are regulated by the coreceptors CD19 and CD22 are not known. The mitogen-activated protein (MAP) kinases ERK2, JNK, and p38 couple extracellular signals to transcriptional responses. The capacity of mIg to activate these MAP kinases is synergisticall...

journal_title：Immunity

authors： Tooze RM,Doody GM,Fearon DT

更新日期：1997-07-01 00:00:00

abstract：:Eradication of a given pathogen is dependent on the selective differentiation of T helper (Th) cells into Th1 or Th2 types. We show here that T cells from mice lacking the transcription factor IRF-1 fail to mount Th1 responses and instead exclusively undergo Th2 differentiation in vitro. Compromised Th1 differentiatio...

journal_title：Immunity

authors： Taki S,Sato T,Ogasawara K,Fukuda T,Sato M,Hida S,Suzuki G,Mitsuyama M,Shin EH,Kojima S,Taniguchi T,Asano Y

更新日期：1997-06-01 00:00:00

abstract：:Peptide-specific down-regulation of T cell responses may represent a powerful tool to intervene in autoimmune diseases or graft rejections. It is therefore important to know whether peptide treatment tolerizes both naive and antigen-experienced memory T lymphocytes. Here we show that a major histocompatibility complex...

journal_title：Immunity

authors： Aichele P,Brduscha-Riem K,Oehen S,Odermatt B,Zinkernagel RM,Hengartner H,Pircher H

更新日期：1997-05-01 00:00:00

abstract：:Human cytomegalovirus inhibits peptide import into the endoplasmic reticulum (ER) by the MHC-encoded TAP peptide transporter. We identified the open reading frame US6 to mediate this effect. Expression of the 21 kDa US6 glycoprotein in human cytomegalovirus-infected cells correlates with the inhibition of peptide tran...

journal_title：Immunity

authors： Hengel H,Koopmann JO,Flohr T,Muranyi W,Goulmy E,Hämmerling GJ,Koszinowski UH,Momburg F

更新日期：1997-05-01 00:00:00

abstract：:Studies of T cell anergy in vitro have led to the widely accepted view that anergy is induced by T cell antigen recognition without costimulation. We show that the induction of T cell anergy in vivo is due to an abortive T cell response that requires recognition of B7 molecules, since blocking B7 maintains T cells in ...

journal_title：Immunity

authors： Perez VL,Van Parijs L,Biuckians A,Zheng XX,Strom TB,Abbas AK

更新日期：1997-04-01 00:00:00

abstract：:HLA-DM (DM) is a nonclassical MHC class II molecule that interacts with classical MHC II molecules in acidic compartments. During this association DM is supposed to catalyze the release of invariant chain (Ii)-derived CLIP peptides, as well as other peptides bound with low kinetic stability. Here we provide evidence t...

journal_title：Immunity

authors： Kropshofer H,Arndt SO,Moldenhauer G,Hämmerling GJ,Vogt AB

更新日期：1997-03-01 00:00:00

abstract：:We have characterized the CD1b-mediated presentation pathway for the mycobacterial lipoglycan lipoarabinomannan (LAM) in monocyte-derived antigen-presenting cells. The macrophage mannose receptor (MR) was responsible for uptake of LAM. Antagonism of MR function inhibited both the internalization of LAM and the present...

journal_title：Immunity

authors： Prigozy TI,Sieling PA,Clemens D,Stewart PL,Behar SM,Porcelli SA,Brenner MB,Modlin RL,Kronenberg M

更新日期：1997-02-01 00:00:00

abstract：:Neonatal female mice injected with the self ZP3 peptide are not tolerant to the peptide; they develop autoimmune ovarian disease (AOD) and autoantibody response 5 weeks later. ZP3 challenge leads to severe AOD and ZP3-specific T cell and antibody responses. In contrast, neonatal tolerance to foreign ZP3 peptide is est...

journal_title：Immunity

authors： Garza KM,Griggs ND,Tung KS

更新日期：1997-01-01 00:00:00

abstract：:A major mechanism maintaining immune tolerance is the deletion of potentially autoreactive thymocytes by apoptosis during development in the thymus. Previous reports suggest that apoptosis is induced by high avidity signals transduced via the T cell receptor; however, the role of signals transduced by other cell surfa...

journal_title：Immunity

authors： Castro JE,Listman JA,Jacobson BA,Wang Y,Lopez PA,Ju S,Finn PW,Perkins DL

更新日期：1996-12-01 00:00:00

abstract：:Two families of protein tyrosine kinases (PTKs), the Src and Syk/ZAP-70 families, are required for T cell development. Lck is the major Src family member required for thymopoiesis, since there is a severe deficit of CD4+CD8+ thymocytes and mature T cells in its absence. However, some peripheral T cells are evident in ...

journal_title：Immunity

authors： van Oers NS,Lowin-Kropf B,Finlay D,Connolly K,Weiss A

更新日期：1996-11-01 00:00:00

abstract：:Cytokine regulation of B cell development was analyzed using interleukin-2 (IL-2)-induced transcription of the J chain gene as a model system. A nuclear target of the IL-2 signal was identified as the Pax5 transcription factor, BSAP, which recognizes a negative regulatory motif in the J chain promoter. Functional assa...

journal_title：Immunity

authors： Rinkenberger JL,Wallin JJ,Johnson KW,Koshland ME

更新日期：1996-10-01 00:00:00

abstract：:C57BI/6 mice infected with mouse hepatitis virus, strain JHM (MHV-JHM) develop a chronic demyelinating encephalomyelitis. Infectious virus can be isolated only from symptomatic mice. In C57BI/6 mice, two CD8+ T cell epitopes within the MHV-JHM surface glycoprotein were previously identified. Here, we show that mutatio...

journal_title：Immunity

authors： Pewe L,Wu GF,Barnett EM,Castro RF,Perlman S

更新日期：1996-09-01 00:00:00

abstract：:We have measured the absolute numbers of EBV-infected B cells in the peripheral blood of healthy persistently infected individuals. Single measurements on a panel of 15 healthy individuals demonstrate that the frequency varies over a wide range from 1-50 per 10(6) B cells. Repeat measurements over 1-3.5 years on sever...

journal_title：Immunity

authors： Khan G,Miyashita EM,Yang B,Babcock GJ,Thorley-Lawson DA

更新日期：1996-08-01 00:00:00

abstract：:We examined the relationship between cell death and tolerance induction following antigen injection into the anterior chamber of the eye. Our data show that when inflammatory cells undergo apoptosis following infection with HSV-1, tolerance to the virus was observed. In contrast, when cell death was absent due to defe...

journal_title：Immunity

authors： Griffith TS,Yu X,Herndon JM,Green DR,Ferguson TA

更新日期：1996-07-01 00:00:00

abstract：:T lymphocyte receptor CTLA-4 binds costimulatory molecules CD80 (B7-1) and CD86 (B7-2) with high avidity and negatively regulates T cell activation. CTLA-4 functions at the cell surface, yet is primarily localized in intracellular vesicles. Here, we demonstrate cycling of CTLA-4 between intracellular stores and the ce...

journal_title：Immunity

authors： Linsley PS,Bradshaw J,Greene J,Peach R,Bennett KL,Mittler RS

更新日期：1996-06-01 00:00:00

abstract：:Tristetraprolin (TTP) is a widely expressed potential transcription factor that contains two unusual CCCH zinc fingers and is encoded by the immediate-early response gene, Zfp-36. Mice made deficient in TTP by gene targeting appeared normal at birth, but soon manifested marked medullary and extramedullary myeloid hype...

journal_title：Immunity

authors： Taylor GA,Carballo E,Lee DM,Lai WS,Thompson MJ,Patel DD,Schenkman DI,Gilkeson GS,Broxmeyer HE,Haynes BF,Blackshear PJ

更新日期：1996-05-01 00:00:00

abstract：:Destruction of li by proteolysis is required for MHC class II molecules to bind antigenic peptides, and for transport of the resulting complexes to the cell surface. The cysteine protease cathepsin S is highly expressed in spleen, lymphocytes, monocytes, and other class II-positive cells, and is inducible with interfe...

journal_title：Immunity

authors： Riese RJ,Wolf PR,Brömme D,Natkin LR,Villadangos JA,Ploegh HL,Chapman HA

更新日期：1996-04-01 00:00:00

abstract：:We and others have defined a transcriptional silencer critical for the proper expression of the CD4 gene at all stages of T cell development. In this report, we use biochemical techniques to identify three different factor-binding sites within the CD4 silencer, denoted sites I, II, and III. Using transgenic analyses, ...

journal_title：Immunity

authors： Duncan DD,Adlam M,Siu G

更新日期：1996-03-01 00:00:00

abstract：:Mature T cells comprise two mutually exclusive lineages expressing heterodimeric alpha beta or gamma delta antigen receptors. During development, beta, gamma, and delta genes rearrange before alpha, and mature gamma delta cells arise in the thymus prior to alpha beta cells. The mechanism underlying commitment of immat...

journal_title：Immunity

authors： Wilson A,de Villartay JP,MacDonald HR

更新日期：1996-01-01 00:00:00

abstract：:We have generated a site-directed transgenic (sd-tg) mouse model in which the JH locus has been replaced with a rearranged VDJ coding for the heavy chain of an anti-DNA antibody. In these mice, B cells expressing the anti-dsDNA specificity are negatively regulated. We observe a novel mechanism for B cell tolerance, re...

journal_title：Immunity

authors： Chen C,Nagy Z,Prak EL,Weigert M

更新日期：1995-12-01 00:00:00